The effect of Bronchogen, a tetrapeptide, was investigated on the bronchial epithelium and inflammatory activity in the lungs of rats with chronic obstructive pulmonary disease (COPD).
The results showed that bronchogen treatment normalized the cellular composition and profile of pro-inflammatory cytokines and enzymes in the bronchoalveolar space, resulting in decreased activity of neutrophilic inflammation in the lungs. Additionally, the structure of the bronchial epithelium, which was disturbed in the COPD model, was restored, accompanied by an increase in secretory immunoglobulin A and surfactant protein B, markers for local immunity and reducing alveolar surface tension, respectively.
Titova ON, Kuzubova NA, Lebedeva ES, Preobrazhenskaya TN, Surkova EA, Dvorakovskaya IV. [ANTIINFLAMMATORY AND REGENERATIVE EFFECT OF PEPTIDE THERAPY IN THE MODEL OF OBSTRUCTIVE LUNG PATHOLOGY]. Ross Fiziol Zh Im I M Sechenova. 2017 Feb;103(2):201-8. Russian. PMID: 30199201.