Glutathione deficiency leads to oxidative stress, which plays a significant role in aging and the development of various diseases such as kwashiorkor, seizures, Alzheimer’s disease, Parkinson’s disease, liver disease, cystic fibrosis, sickle cell anemia, HIV/AIDS, cancer, heart attack, stroke, and diabetes. Understanding the nutritional regulation of GSH metabolism is vital for developing effective strategies to enhance overall health and treat these diseases.